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Principles of Drug TherapyDosingand Prescribing in Chronic Kidney Disease and Renal Replacement Therapy.
Risk of raised intracranial hypertension with systemic retinoidsacitretinisotretinoinalitretinoinReduced bioavailability of tetracyclines with ironaluminiummagnesiumcalciumrifampicincelestipol and anticonvulsants Increased renal toxicity with diuretics May increase lithium concentrationswhich can lead to toxicity.
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Tetracyclines are well absorbed after oral administration and are probably active against parasite protein synthesisSide effects include gastrointestinal distressphotosensitivity and vaginal candidiasis.
Tetracycline and minocycline are excreted primarily in urineDoxycycline is excreted primarily in the intestinal tract.
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